Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

Regnase-1 is an RNase that directly cleaves mRNAs of inflammatory genes such as IL-6 and IL-12p40, and negatively regulates cellular inflammatory responses. Here, we report the structures of four domains of Regnase-1 from Mus musculus—the N-terminal domain (NTD), PilT N-terminus like (PIN) domain, z...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Yokogawa, Mariko, Tsushima, Takashi, Noda, Nobuo N., Kumeta, Hiroyuki, Enokizono, Yoshiaki, Yamashita, Kazuo, Standley, Daron M., Takeuchi, Osamu, Akira, Shizuo, Inagaki, Fuyuhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772114/
https://ncbi.nlm.nih.gov/pubmed/26927947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22324
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares