Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs

Regnase-1-mediated mRNA decay (RMD), in which inflammatory mRNAs harboring specific stem–loop structures are degraded, is a critical part of proper immune homeostasis. Prior to initial translation, Regnase-1 associates with target stem–loops but does not carry out endoribonucleolytic cleavage. Singl...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Mino, Takashi, Iwai, Noriki, Endo, Masayuki, Inoue, Kentaro, Akaki, Kotaro, Hia, Fabian, Uehata, Takuya, Emura, Tomoko, Hidaka, Kumi, Suzuki, Yutaka, Standley, Daron M, Okada-Hatakeyama, Mariko, Ohno, Shigeo, Sugiyama, Hiroshi, Yamashita, Akio, Takeuchi, Osamu
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
RNA and RNA-protein complexes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145602/
https://ncbi.nlm.nih.gov/pubmed/31329944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz628
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