Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)

Hepatitis C virus (HCV) infects hepatocytes but not dendritic cells (DCs), but DCs effectively mature in response to HCV-infected hepatocytes. Using gene-disrupted mice and hydrodynamic injection strategy, we found the MAVS pathway to be crucial for induction of type III interferons (IFNs) in respon...

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Библиографические подробности
Главные авторы: Masato Nakai, Hiroyuki Oshiumi, Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, Naoya Sakamoto
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2015-10-01
Серии:Sensors
Предметы:
Hepatitis C virus (HCV)
interferon (IFN)-lambda
dendritic cells (DCs)
Toll-like receptor 3 (TLR3)
natural killer (NK) cell
cytotoxic T lymphocyte (CTL)
Online-ссылка:http://www.mdpi.com/1424-8220/15/10/27160
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