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Fjord-region Benzo[g]chrysene-11,12-dihydrodiol and Benzo[c]phenanthrene-3,4-dihydrodiol as Substrates for Rat Liver Dihydrodiol Dehydrogenase (AKR1C9): Structural Basis for Stereochemical Preference
This study demonstrates that benzo[g]chrysene-11,12-dihydrodiol (B[g]C-11,12-dihydrodiol) derived from the fjord-region parent hydrocarbon B[g]C is oxidized by rat AKR1C9 with a k(cat)/K(m) 100 times greater than that observed with the commonly studied bay-region benzo[a]pyrene-7,8-dihydrodiol (B[a]...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440589/ https://ncbi.nlm.nih.gov/pubmed/18251511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7003695 |
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