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High Throughput Screening Reveals Several New Classes of Glutamate Dehydrogenase Inhibitors
Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in insulin secretion by pancreatic β-cells. The most compelling evidence of this comes from features of the hyperinsulism/hyperammonemia (HI/HA) syndrome where a dominant mutation causes the loss of inhibition by GTP, and from st...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440342/ https://ncbi.nlm.nih.gov/pubmed/18044977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7018783 |
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