Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

The amyloid hypothesis states that a variety of neurotoxic β-amyloid (Aβ) species contribute to the pathogenesis of Alzheimer's disease. Accordingly, a key determinant of disease onset and progression is the appropriate balance between Aβ production and clearance. Enzymes responsible for the de...

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Detalhes bibliográficos
Main Authors: Jacobsen, J. Steven, Comery, Thomas A., Martone, Robert L., Elokdah, Hassan, Crandall, David L., Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M., Das, Indranil, Arias, Robert L., Bard, Jonathan, Riddell, David, Gardell, Stephen J., Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P., Bjornsson, Thorir, Reinhart, Peter H., Pangalos, Menelas N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438386/
https://ncbi.nlm.nih.gov/pubmed/18559859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710823105
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