Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

Inheritance of the apoE4 allele (ε4) increases the risk of developing Alzheimer's disease; however, the mechanisms underlying this association remain elusive. Recent data suggest that inheritance of ε4 may lead to reduced apoE protein levels in the CNS. We therefore examined apoE protein levels...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Riddell, David R., Zhou, Hua, Atchison, Kevin, Warwick, Helen K., Atkinson, Peter J., Jefferson, Julius, Xu, Lin, Aschmies, Suzan, Kirksey, Yolanda, Hu, Yun, Wagner, Erik, Parratt, Adrienne, Xu, Jane, Li, Zhuting, Zaleska, Margaret M., Jacobsen, J. Steve, Pangalos, Menelas N., Reinhart, Peter H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671315/
https://ncbi.nlm.nih.gov/pubmed/18987181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1972-08.2008
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