Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma

Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We show that a common G/C polymorphism (rs2910164) within the pre-miR-146a sequence reduced the amount of pre- and mature miR-146a from the C allele 1.9- and 1.8-fold, respec...

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Bibliografiska uppgifter
Huvudupphovsmän: Jazdzewski, Krystian, Murray, Elizabeth L., Franssila, Kaarle, Jarzab, Barbara, Schoenberg, Daniel R., de la Chapelle, Albert
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438239/
https://ncbi.nlm.nih.gov/pubmed/18474871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802682105
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