Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer

Prior work has shown that heterozygosity G/C of single nucleotide polymorphism (SNP rs2910164) within the precursor of microRNA-146a predisposes to PTC (odds ratio = 1.62, P = 0.000007) although the mechanism was unclear. Here, we show that GC heterozygotes differ from both GG and CC homozygotes by...

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Détails bibliographiques
Auteurs principaux: Jazdzewski, Krystian, Liyanarachchi, Sandya, Swierniak, Michal, Pachucki, Janusz, Ringel, Matthew D., Jarzab, Barbara, de la Chapelle, Albert
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635764/
https://ncbi.nlm.nih.gov/pubmed/19164563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812591106
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