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Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We show that a common G/C polymorphism (rs2910164) within the pre-miR-146a sequence reduced the amount of pre- and mature miR-146a from the C allele 1.9- and 1.8-fold, respec...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2438239/ https://ncbi.nlm.nih.gov/pubmed/18474871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802682105 |
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