Prostaglandin E(2) glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFκB activity

BACKGROUND AND PURPOSE: Recombinant cyclooxygenase-2 (COX-2) oxygenates 2-arachidonoylglycerol (2-AG) in vitro. We examined whether prostaglandin E(2) glycerol ester (PGE(2)-G), a COX-2 metabolite of 2-AG, occurs endogenously and affects nociception and immune responses. EXPERIMENTAL APPROACH: Using...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hu, S Shu-Jung, Bradshaw, H B, Chen, J S-C, Tan, B, Walker, J Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2008
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2437899/
https://ncbi.nlm.nih.gov/pubmed/18297109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.33
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