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Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute Inflammatory Liver Injury in Mice

Oxidative stress-mediated destruction of normal parenchymal cells during hepatic inflammatory responses contributes to the pathogenesis of immune-mediated hepatitis and is implicated in the progression of acute inflammatory liver injury to chronic inflammatory liver disease. The transcription factor...

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Detalhes bibliográficos
Main Authors: Osburn, William O., Yates, Melinda S., Dolan, Patrick D., Liby, Karen T., Sporn, Michael B., Taguchi, Keiko, Yamamoto, Masayuki, Kensler, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435415/
https://ncbi.nlm.nih.gov/pubmed/18417483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn079
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