Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome

Smith-Lemli-Opitz syndrome (SLOS) is caused by an inherited defect in the last step in cholesterol (Chol) biosynthesis, leading to abnormal accumulation of 7-dehydrocholesterol and decreased Chol levels. Progressive retinal degeneration occurs in an animal model of SLOS, induced by treating rats wit...

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Main Authors: Boesze-Battaglia, Kathleen, Damek-Poprawa, Monika, Mitchell, Drake C., Greeley, Laura, Brush, Richard S., Anderson, Robert E., Richards, Michael J., Fliesler, Steven J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431111/
https://ncbi.nlm.nih.gov/pubmed/18344409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800031-JLR200
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