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Retinal Degeneration in a Rodent Model of Smith-Lemli-Opitz Syndrome: Electrophysiologic, Biochemical, and Morphologic Features
OBJECTIVE: To assess the electrophysiologic, histologic, and biochemical features of an animal model of Smith-Lemli-Opitz syndrome (SLOS). METHODS: Sprague-Dawley rats were treated with AY9944, a selective inhibitor of 3β-hydroxysterol-Δ7-reductase (the affected enzyme in SLOS). Dark- and light-adap...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865831/ https://ncbi.nlm.nih.gov/pubmed/15302661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archopht.122.8.1190 |
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