Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

Selectin-ligand interactions (bonds) mediate leukocyte rolling on vascular surfaces. The molecular basis for differential ligand recognition by selectins is poorly understood. Here, we show that substituting one residue (A108H) in the lectin domain of L-selectin increased its force-free affinity for...

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Détails bibliographiques
Auteurs principaux: Klopocki, Arkadiusz G., Yago, Tadayuki, Mehta, Padmaja, Yang, Jun, Wu, Tao, Leppänen, Anne, Bovin, Nicolai V., Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Glycobiology and Extracellular Matrices
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431087/
https://ncbi.nlm.nih.gov/pubmed/18250165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709785200
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