Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

Selectin-ligand interactions (bonds) mediate leukocyte rolling on vascular surfaces. The molecular basis for differential ligand recognition by selectins is poorly understood. Here, we show that substituting one residue (A108H) in the lectin domain of L-selectin increased its force-free affinity for...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Klopocki, Arkadiusz G., Yago, Tadayuki, Mehta, Padmaja, Yang, Jun, Wu, Tao, Leppänen, Anne, Bovin, Nicolai V., Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
Onderwerpen:
Glycobiology and Extracellular Matrices
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431087/
https://ncbi.nlm.nih.gov/pubmed/18250165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709785200
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items