Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

Selectin-ligand interactions (bonds) mediate leukocyte rolling on vascular surfaces. The molecular basis for differential ligand recognition by selectins is poorly understood. Here, we show that substituting one residue (A108H) in the lectin domain of L-selectin increased its force-free affinity for...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Klopocki, Arkadiusz G., Yago, Tadayuki, Mehta, Padmaja, Yang, Jun, Wu, Tao, Leppänen, Anne, Bovin, Nicolai V., Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2008
विषय:
Glycobiology and Extracellular Matrices
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431087/
https://ncbi.nlm.nih.gov/pubmed/18250165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709785200
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