Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase

Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor. During Arg hydroxylation, H(4)B acts as a one-electron donor and is then presumed to redox cycle (i.e....

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Главные авторы: Wei, Chin-Chuan, Wang, Zhi-Qiang, Tejero, Jesús, Yang, Ya-Ping, Hemann, Craig, Hille, Russ, Stuehr, Dennis J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Enzyme Catalysis and Regulation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431086/
https://ncbi.nlm.nih.gov/pubmed/18283102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709250200
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