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Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase
Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor. During Arg hydroxylation, H(4)B acts as a one-electron donor and is then presumed to redox cycle (i.e....
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2431086/ https://ncbi.nlm.nih.gov/pubmed/18283102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709250200 |
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