The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid-Imidazolide Alters Transforming Growth Factor β-dependent Signaling and Cell Migration by Affecting the Cytoskeleton and the Polarity Complex

The anti-tumor synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO)-imidazolide (CDDO-Im) ectopically activates the transforming growth factor β (TGFβ)-Smad pathway and extends the duration of signaling by an undefined mechanism. Here we show that CDDO-Imdependent persistence...

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Autors principals: To, Ciric, Kulkarni, Sarang, Pawson, Tony, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., Wrana, Jeffrey L., Di Guglielmo, Gianni M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431070/
https://ncbi.nlm.nih.gov/pubmed/18283107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M704064200
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