Targeted Gene Knock In and Sequence Modulation Mediated by a Psoralen-linked Triplex-forming Oligonucleotide

Information from exogenous donor DNA can be introduced into the genome via homology-directed repair (HDR) pathways. These pathways are stimulated by double strand breaks and by DNA damage such as interstrand cross-links. We have employed triple helix-forming oligonucleotides linked to psoralen (pso-...

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Detalhes bibliográficos
Main Authors: Majumdar, Alokes, Muniandy, Parameswary A., Liu, Jia, Liu, Ji-lan, Liu, Su-ting, Cuenoud, Bernard, Seidman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431054/
https://ncbi.nlm.nih.gov/pubmed/18303025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800607200
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