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The Tec Family Tyrosine Kinase Btk Regulates RANKL-induced Osteoclast Maturation

A spontaneous mutation in Bruton's tyrosine kinase (Btk) induces a defect in B-cell development that results in the immunodeficiency diseases X-linked agammaglobulinemia in humans and X-linked immunodeficiency (Xid) in mice. Here we show an unexpected role of Btk in osteoclast formation. When b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lee, Seoung Hoon, Kim, Taesoo, Jeong, Daewon, Kim, Nacksung, Choi, Yongwon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431049/
https://ncbi.nlm.nih.gov/pubmed/18281276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708935200
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