Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

The 2′,3′-dideoxy-3′-thiacytidine drug-resistant M184I HIV-1 reverse transcriptase (RT) has been shown to synthesize DNA with decreased processivity compared with the wild-type RT. M184A displays an even more severe processivity defect. However, the basis of this decreased processivity has been uncl...

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Main Authors: Gao, Lu, Hanson, Mark Nils, Balakrishnan, Mini, Boyer, Paul L., Roques, Bernard P., Hughes, Stephen H., Kim, Baek, Bambara, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431043/
https://ncbi.nlm.nih.gov/pubmed/18218634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710148200
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