Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure in Macrophage

We characterized HIV-1 reverse transcriptase (RT) variants either with or without the (-)-2′,3′-deoxy-3′-thiacytidine-resistant M184I mutation isolated from a single HIV-1 infected patient. First, unlike variants with wild-type M184, M184I RT variants displayed significantly reduced DNA polymerase a...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Jamburuthugoda, Varuni K, Santos-Velazquez, Jose M., Skasko, Mark, Operario, Darwin J., Purohit, Vandana, Chugh, Pauline, Szymanski, Erika A., Wedekind, Joseph E., Bambara, Robert A., Kim, Baek
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2008
Ábhair:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431026/
https://ncbi.nlm.nih.gov/pubmed/18218633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710149200
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla