Macrophage tropism of HIV-1 depends upon efficient cellular dNTP utilization by reverse transcriptase

Retroviruses utilize cellular dNTPs to perform proviral DNA synthesis in infected host cells. Unlike oncoretroviruses, which replicate only in dividing cells, lentiviruses, such as HIV-1 and SIV, are capable of efficiently replicating in non-dividing cells (terminally differentiated macrophages) as...

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Autori principali: Diamond, Tracy L., Roshal, Mikhail, Jamburuthugoda, Varuni K., Reynolds, Holly M., Merriam, Aaron R., Lee, Kwi Y., Balakrishnan, Mini, Bambara, Robert A., Planelles, Vicente, Dewhurst, Stephen, Kim, Baek
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2004
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351161/
https://ncbi.nlm.nih.gov/pubmed/15452123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M408573200
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