Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase-activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMP-activated Protein Kinase Activation

Insulin increases glucose transport by stimulating the trafficking of intracellular GLUT4 to the cell surface, a process known as GLUT4 translocation. A key protein in signaling this process is AS160, a Rab GTPase-activating protein (GAP) whose activity appears to be suppressed by Akt phosphorylatio...

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Bibliografiske detaljer
Main Authors: Chavez, Jose A., Roach, William G., Keller, Susanna R., Lane, William S., Lienhard, Gustav E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431020/
https://ncbi.nlm.nih.gov/pubmed/18258599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708934200
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