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Crystal Structures of Human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating Protein (RabGAP) Domains Reveal Critical Elements for GLUT4 Translocation

We have solved the x-ray crystal structures of the RabGAP domains of human TBC1D1 and human TBC1D4 (AS160), at 2.2 and 3.5 Å resolution, respectively. Like the yeast Gyp1p RabGAP domain, whose structure was solved previously in complex with mouse Rab33B, the human TBC1D1 and TBC1D4 domains both have...

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Библиографические подробности
Главные авторы: Park, Sang-Youn, Jin, Wanzhu, Woo, Ju Rang, Shoelson, Steven E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093885/
https://ncbi.nlm.nih.gov/pubmed/21454505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217323
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