Malignant transformation initiated by Mll-AF9: Gene dosage and critical target cells

The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined. In a study of target cells and oncogene dosage, we found that Mll-AF9, when under endogenous regulatory control, efficiently transformed LSK (Lin(−) Sca1(+) c-kit(+)) s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Weili, Kumar, Ashish R., Hudson, Wendy A., Li, Quanzhi, Wu, Baolin, Staggs, Rodney A., Lund, Erik A., Sam, Thien N., Kersey, John H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430522/
https://ncbi.nlm.nih.gov/pubmed/18455126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.03.005
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