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Malignant transformation initiated by Mll-AF9: Gene dosage and critical target cells
The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined. In a study of target cells and oncogene dosage, we found that Mll-AF9, when under endogenous regulatory control, efficiently transformed LSK (Lin(−) Sca1(+) c-kit(+)) s...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2430522/ https://ncbi.nlm.nih.gov/pubmed/18455126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.03.005 |
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