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Universal Metastability of Sickle Hemoglobin Polymerization

Sickle hemoglobin (HbS) polymerization occurs when deoxy HbS concentration exceeds a well-defined solubility. In experiments using sickle hemoglobin droplets suspended in oil, it has been shown that when polymerization ceases the monomer concentration is above equilibrium solubility. We find that th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Weng, Weijun, Aprelev, Alexey, Briehl, Robin W., Ferrone, Frank A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430085/
https://ncbi.nlm.nih.gov/pubmed/18308336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.083
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