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The Oxidatively-Induced DNA Lesions 8,5′-Cyclo-2′-Deoxyadenosine and 8-Hydroxy-2′-Deoxyadenosine Are Strongly Resistant to Acid-Induced Hydrolysis of the Glycosidic Bond

The 8,5’-cyclopurine-2’-deoxynucleosides (cPu) are unique oxidatively-induced DNA lesions in that they are specifically repaired by NER. In the absence of NER, a possible mechanism for cPu removal is spontaneous glycosidic bond hydrolysis followed by enzymic processing. Such a mechanism could be sig...

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Sonraí Bibleagrafaíochta
Main Authors: Theruvathu, Jacob A., Jaruga, Pawel, Dizdaroglu, Miral, Brooks, PJ
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430076/
https://ncbi.nlm.nih.gov/pubmed/17692895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2007.06.006
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