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Roles of p15(Ink4b) and p16(Ink4a) in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia

Inactivation of p15(Ink4b) expression by promoter hypermethylation occurs in up to 80% of acute myeloid leukemia (AML) cases and is particularly common in the FAB-M2 subtype of AML, which is characterized by the presence of the RUNX1-ETO translocation in 40% of cases. To establish whether the loss o...

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Detalhes bibliográficos
Main Authors: Ko, Rose M., Kim, Hyung-Gyoon, Wolff, Linda, Klug, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430055/
https://ncbi.nlm.nih.gov/pubmed/18037485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2007.10.012
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