Distinct classes of c-Kit–activating mutations differ in their ability to promote RUNX1-ETO–associated acute myeloid leukemia

The t(8;21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO(+) patient samples, differing classes of activating c-KIT receptor tyrosine kinase mutations have been observed. The most common (12%-48%) involves mutations, such...

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Main Authors: Nick, Heidi J., Kim, Hyung-Gyoon, Chang, Chia-Wei, Harris, Kevin W., Reddy, Vishnu, Klug, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286215/
https://ncbi.nlm.nih.gov/pubmed/21937700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-338228
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