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Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia
Inactivation of p15INK4b, an inhibitor of cyclin-dependent kinases, through DNA methylation is one of the most common epigenetic abnormalities in myeloid leukemia. Although this suggests a key role for this protein in myeloid disease suppression, experimental evidence to support this has not been re...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society of Hematology
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924230/ https://ncbi.nlm.nih.gov/pubmed/20457873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-238360 |
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