Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus

Patients with Doublecortin (DCX) mutations have severe cortical malformations associated with mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but have discrete hippocampal defects. We questioned the functional consequences of these defects and report...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Nosten-Bertrand, Marika, Kappeler, Caroline, Dinocourt, Céline, Denis, Cécile, Germain, Johanne, Dinh Tuy, Françoise Phan, Verstraeten, Soraya, Alvarez, Chantal, Métin, Christine, Chelly, Jamel, Giros, Bruno, Miles, Richard, Depaulis, Antoine, Francis, Fiona
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2008
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429962/
https://ncbi.nlm.nih.gov/pubmed/18575605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002473
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