Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus

Patients with Doublecortin (DCX) mutations have severe cortical malformations associated with mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but have discrete hippocampal defects. We questioned the functional consequences of these defects and report...

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Autores principales: Nosten-Bertrand, Marika, Kappeler, Caroline, Dinocourt, Céline, Denis, Cécile, Germain, Johanne, Dinh Tuy, Françoise Phan, Verstraeten, Soraya, Alvarez, Chantal, Métin, Christine, Chelly, Jamel, Giros, Bruno, Miles, Richard, Depaulis, Antoine, Francis, Fiona
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429962/
https://ncbi.nlm.nih.gov/pubmed/18575605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002473
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