Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus

Patients with Doublecortin (DCX) mutations have severe cortical malformations associated with mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but have discrete hippocampal defects. We questioned the functional consequences of these defects and report...

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Detalhes bibliográficos
Main Authors: Nosten-Bertrand, Marika, Kappeler, Caroline, Dinocourt, Céline, Denis, Cécile, Germain, Johanne, Dinh Tuy, Françoise Phan, Verstraeten, Soraya, Alvarez, Chantal, Métin, Christine, Chelly, Jamel, Giros, Bruno, Miles, Richard, Depaulis, Antoine, Francis, Fiona
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429962/
https://ncbi.nlm.nih.gov/pubmed/18575605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002473
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