Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus

Patients with Doublecortin (DCX) mutations have severe cortical malformations associated with mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but have discrete hippocampal defects. We questioned the functional consequences of these defects and report...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nosten-Bertrand, Marika, Kappeler, Caroline, Dinocourt, Céline, Denis, Cécile, Germain, Johanne, Dinh Tuy, Françoise Phan, Verstraeten, Soraya, Alvarez, Chantal, Métin, Christine, Chelly, Jamel, Giros, Bruno, Miles, Richard, Depaulis, Antoine, Francis, Fiona
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2008
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429962/
https://ncbi.nlm.nih.gov/pubmed/18575605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002473
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