Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis

BACKGROUND: The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using te...

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Autors principals: Chan, Timothy A, Glockner, Sabine, Yi, Joo Mi, Chen, Wei, Van Neste, Leander, Cope, Leslie, Herman, James G, Velculescu, Victor, Schuebel, Kornel E, Ahuja, Nita, Baylin, Stephen B
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429944/
https://ncbi.nlm.nih.gov/pubmed/18507500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050114
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