The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles

Endoreplicating cells undergo multiple rounds of DNA replication leading to polyploidy or polyteny. Oscillation of Cyclin E (CycE)-dependent kinase activity is the main driving force in Drosophila endocycles. High levels of CycE–Cdk2 activity trigger S phase, while down-regulation of CycE-Cdk2 activ...

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Autori principali: Zielke, Norman, Querings, Silvia, Rottig, Carmen, Lehner, Christian, Sprenger, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2008
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428065/
https://ncbi.nlm.nih.gov/pubmed/18559483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.469108
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