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The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles
Endoreplicating cells undergo multiple rounds of DNA replication leading to polyploidy or polyteny. Oscillation of Cyclin E (CycE)-dependent kinase activity is the main driving force in Drosophila endocycles. High levels of CycE–Cdk2 activity trigger S phase, while down-regulation of CycE-Cdk2 activ...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2428065/ https://ncbi.nlm.nih.gov/pubmed/18559483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.469108 |
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