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Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function

Rca1 (regulator of Cyclin A)/Emi (early mitotic inhibitor) proteins are essential inhibitors of the anaphase-promoting complex/cyclosome (APC/C). In Drosophila, Rca1 is required during G2 to prevent premature cyclin degradation by the Fizzy-related (Fzr)-dependent APC/C activity. Here, we present a...

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Bibliographische Detailangaben
Hauptverfasser: Zielke, Norman, Querings, Silvia, Grosskortenhaus, Ruth, Reis, Tânia, Sprenger, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794692/
https://ncbi.nlm.nih.gov/pubmed/17099689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400851
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