Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis; however, the relative contribution of these mutations to the initiation of osteosarcoma is unclear. We describe here...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Walkley, Carl R., Qudsi, Rameez, Sankaran, Vijay G., Perry, Jennifer A., Gostissa, Monica, Roth, Sanford I., Rodda, Stephen J., Snay, Erin, Dunning, Patricia, Fahey, Frederic H., Alt, Frederick W., McMahon, Andrew P., Orkin, Stuart H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2008
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428063/
https://ncbi.nlm.nih.gov/pubmed/18559481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1656808
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