Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis; however, the relative contribution of these mutations to the initiation of osteosarcoma is unclear. We describe here...

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Detalhes bibliográficos
Main Authors: Walkley, Carl R., Qudsi, Rameez, Sankaran, Vijay G., Perry, Jennifer A., Gostissa, Monica, Roth, Sanford I., Rodda, Stephen J., Snay, Erin, Dunning, Patricia, Fahey, Frederic H., Alt, Frederick W., McMahon, Andrew P., Orkin, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428063/
https://ncbi.nlm.nih.gov/pubmed/18559481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1656808
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