Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH

Antigenic peptide loading of major histocompatibility complex class II molecules is enhanced by lysosomal pH and catalyzed by the HLA-DM molecule. The physical mechanism behind the catalytic activity of DM was investigated by using time-resolved fluorescence anisotropy (TRFA) and fluorescence bindin...

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Bibliographische Detailangaben
Hauptverfasser: Ullrich, H. Joachim, Döring, Klaus, Grüneberg, Ulrike, Jähnig, Fritz, Trowsdale, John, van Ham, S. Marieke
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC24280/
https://ncbi.nlm.nih.gov/pubmed/9371817
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