Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH
Antigenic peptide loading of major histocompatibility complex class II molecules is enhanced by lysosomal pH and catalyzed by the HLA-DM molecule. The physical mechanism behind the catalytic activity of DM was investigated by using time-resolved fluorescence anisotropy (TRFA) and fluorescence bindin...
Sparad:
| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphov: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
National Academy of Sciences
1997
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.24.13163 |
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