Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH

Antigenic peptide loading of major histocompatibility complex class II molecules is enhanced by lysosomal pH and catalyzed by the HLA-DM molecule. The physical mechanism behind the catalytic activity of DM was investigated by using time-resolved fluorescence anisotropy (TRFA) and fluorescence bindin...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ullrich, H. Joachim, Döring, Klaus, Grüneberg, Ulrike, Jähnig, Fritz, Trowsdale, John, van Ham, S. Marieke
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.24.13163
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