טוען...
Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase
Accumulation of senile plaques composed of amyloid β-peptide (Aβ) is a pathological hallmark of Alzheimer disease (AD), and Aβ is generated through the sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Although oxidative stress has been implicated in the AD pathogenesis b...
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| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2427353/ https://ncbi.nlm.nih.gov/pubmed/18436531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800013200 |
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