Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

Accumulation of senile plaques composed of amyloid β-peptide (Aβ) is a pathological hallmark of Alzheimer disease (AD), and Aβ is generated through the sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Although oxidative stress has been implicated in the AD pathogenesis b...

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Detalhes bibliográficos
Main Authors: Shen, Chengyong, Chen, Yongfeng, Liu, Huaqing, Zhang, Kejing, Zhang, Ting, Lin, Anning, Jing, Naihe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427353/
https://ncbi.nlm.nih.gov/pubmed/18436531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800013200
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