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TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Generation of β-amyloid (Aβ) peptide in Alzheimer's disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch. Finding specific modulators for γ-secretase could be a potential avenue to treat the disease. Here, we...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4696454/ https://ncbi.nlm.nih.gov/pubmed/26581893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9876 |
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