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Load and P(i) Control Flux through the Branched Kinetic Cycle of Myosin V

Myosin V is a processive actin-based motor protein that takes multiple 36-nm steps to deliver intracellular cargo to its destination. In the laser trap, applied load slows myosin V heavy meromyosin stepping and increases the probability of backsteps. In the presence of 40 mm phosphate (P(i)), both f...

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Autors principals: Kad, Neil M., Trybus, Kathleen M., Warshaw, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427344/
https://ncbi.nlm.nih.gov/pubmed/18441369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800539200
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