Load and P(i) Control Flux through the Branched Kinetic Cycle of Myosin V

Myosin V is a processive actin-based motor protein that takes multiple 36-nm steps to deliver intracellular cargo to its destination. In the laser trap, applied load slows myosin V heavy meromyosin stepping and increases the probability of backsteps. In the presence of 40 mm phosphate (P(i)), both f...

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Bibliografiske detaljer
Main Authors: Kad, Neil M., Trybus, Kathleen M., Warshaw, David M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427344/
https://ncbi.nlm.nih.gov/pubmed/18441369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800539200
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