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Store-dependent and -independent Modes Regulating Ca(2+) Release-activated Ca(2+) Channel Activity of Human Orai1 and Orai3
We evaluated currents induced by expression of human homologs of Orai together with STIM1 in human embryonic kidney cells. When co-expressed with STIM1, Orai1 induced a large inwardly rectifying Ca(2+)-selective current with Ca(2+)-induced slow inactivation. A point mutation of Orai1 (E106D) altered...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2427323/ https://ncbi.nlm.nih.gov/pubmed/18420579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801536200 |
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